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Change in Brain Thyrotropin-Releasing Hormone (TRH) Mechanism of Amygdaloid Kindled Rats
| Content Provider | Scilit |
|---|---|
| Author | Kajita, Saburo Nakashima, Makoto Okamoto, Motoi Sato, Mitsumoto Ogawa, Norio |
| Copyright Year | 1986 |
| Description | Journal: Psychiatry and clinical neurosciences We reported previously that DN-1417, a potent analog of thyrotropin-releasing hormone (TRH), suppressed both the progression of amygdaloid (AM) kindling and AM kindled seizure. To study a functional role of the cerebral TRH mechanism in AM kindling, immunoreactive TRH (IR-TRH) and specific TRH receptor binding were examined in the rat brains kindled from the left AM. The IR-TRH concentration elevated significantly in the amygdala plus piriform cortex and the hippocampus 24 and 48 hours after the AM kindled convulsion. Such an elevation of IR-TRH was not found 7 days after the last convulsion, indicating that the elevation of IR-TRH was a transient change seen after the AM kindled convulsion. By contrast, the specific TRH receptor binding in the striatum increased 48 hours, 7 and 21 days after the AM kindled convulsion. This indicates that the increase of the specific TRH binding in the striatum was a long-lasting change. The present study suggests that the change in the striatal TRH receptors may be associated with a long-lasting seizure susceptibility of AM kindled rats. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1819.1986.tb03158.x/pdf |
| Ending Page | 347 |
| Page Count | 3 |
| Starting Page | 345 |
| e-ISSN | 14401819 |
| DOI | 10.1111/j.1440-1819.1986.tb03158.x |
| Journal | Psychiatry and clinical neurosciences |
| Issue Number | 3 |
| Volume Number | 40 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1986-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Psychiatry and clinical neurosciences Endocrinology and Metabolism Amygdaloid Kindling Immunoreactive Thyrotropin‐releasing Hormone (ir‐trh) Trh Receptor Binding |
| Content Type | Text |
| Resource Type | Article |
