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Seizures and Thyrotropin-Releasing Hormone (TRH) Neural System in the Rat Brain
| Content Provider | Scilit |
|---|---|
| Author | Ogawa, Norio Kajita, Saburo Sato, Mitsumoto Mori, Akitane |
| Copyright Year | 1985 |
| Description | Journal: Psychiatry and clinical neurosciences In order to study the relationship between seizures and the thyrotropin-releasing hormone (TRH) neural system, immunoreactive TRH (IR-TRH) and TRH receptor binding activity were determined by pentylenetetrazol (PTZ)-induced seizures and amygdaloid (AM) kindling. IR-TRH markedly increased in the septum 40 and 150 seconds after the PTZ injection. A significant increase in the IR-TRH concentrations was also noted in the hippocampus and thalamus/midbrain 40 and 150 seconds after the PTZ injection, respectively. However, no significant changes were observed in the TRH receptor binding before, during or after the PTZ-induced seizures. In addition, a lasting change in the striatal TRH receptors after AM kindling as well as a transient IR-TRH increase in the limbic structures were seen 48 hours after Am-kindled convulsions. TRH and its analog (DN-1417) inhibited PTZ-induced generalized seizures dose-dependently. These findings indicate the involvement of the TRH neural system in seizure mechanisms, and suggest that endogenous TRH may be an antiepileptic substance in the brain. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1819.1985.tb02007.x/pdf |
| Ending Page | 312 |
| Page Count | 4 |
| Starting Page | 309 |
| e-ISSN | 14401819 |
| DOI | 10.1111/j.1440-1819.1985.tb02007.x |
| Journal | Psychiatry and clinical neurosciences |
| Issue Number | 3 |
| Volume Number | 39 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1985-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Psychiatry and clinical neurosciences Endocrinology and Metabolism Pentylenetetrazol (ptz) Amygdaloid Kindling Thyrotropinâreleasing Hormone (trh) Immunoreactive Trh Trh Receptor Binding Prophylactic Effects |
| Content Type | Text |
| Resource Type | Article |
