NDLI: Role of IFNγ in Allograft Tolerance Mediated by $CD4^{+}CD25^{+}$Regulatory T Cells by Induction of IDO in Endothelial Cells

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Role of IFNγ in Allograft Tolerance Mediated by $CD4^{+}CD25^{+}$Regulatory T Cells by Induction of IDO in Endothelial Cells

Content Provider	Scilit
Author	Thebault, P. Condamine, T. Heslan, M. Hill, M. Bernard, I. Saoudi, A. Josien, R. Anegon, I. Cuturi, M. C. Chiffoleau, E.
Copyright Year	2007
Description	Journal: American Journal of Transplantation Regulatory T cells have been described to specifically accumulate at the site of regulation together with effector T cells and antigen-presenting cells, establishing a state of local immune privilege. However the mechanisms of this interplay remain to be defined. We previously demonstrated, in a fully MHC mismatched rat cardiac allograft combination, that a short-term treatment with a deoxyspergualine analogue, LF15-0195, induces long-term allograft tolerance with a specific expansion of regulatory CD4+CD25+T cells that accumulate within the graft. In this study, we show that following transfer of regulatory CD4+T cells to a secondary irradiated recipient, regulatory CD25+Foxp3+ and CD25+Foxp3(-) CD4+T cells accumulate at the graft site and induce graft endothelial cell expression of Indoleamine 2, 3-dioxygenase (IDO) by an IFNgamma-dependent mechanism. Moreover, in vivo transfer of tolerance can be abrogated by blocking IFNgamma or IDO, and anti-IFNgamma reduces the survival/expansion of alloantigen-induced regulatory Foxp3+CD4+T cells. Together, our results demonstrate interrelated mechanisms between regulatory CD4+CD25+T cells and the graft endothelial cells in this local immune privilege, and a key role for IFNgamma and IDO in this process.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2007.01960.x/pdf
Ending Page	2482
Page Count	11
Starting Page	2472
e-ISSN	16006143
DOI	10.1111/j.1600-6143.2007.01960.x
Journal	American Journal of Transplantation
Issue Number	11
Volume Number	7
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2007-11-01
Access Restriction	Open
Subject Keyword	Journal: American Journal of Transplantation Cell Tissue Engineering Endothelial Cells Regulatory T Cells
Content Type	Text
Resource Type	Article

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