NDLI: Genome evolution in ductal carcinomain situ: invasion of the clones

Please wait, while we are loading the content...

Genome evolution in ductal carcinomain situ: invasion of the clones

Content Provider	Scilit
Author	Casasent, Anna K. Edgerton, Mary Navin, Nicholas E.
Copyright Year	2016
Description	Journal: The Journal of Pathology Ductal carcinoma in situ (DCIS) is the most frequently diagnosed early-stage breast cancer. Only a subset of patients progress to invasive ductal carcinoma (IDC), and this presents a formidable clinical challenge for determining which patients to treat aggressively and which patients to monitor without therapeutic intervention. Understanding the molecular and genomic basis of invasion has been difficult to study in DCIS cancers due to several technical obstacles, including low tumour cellularity, lack of fresh-frozen tissues, and intratumour heterogeneity. In this review, we discuss the role of intratumour heterogeneity in the progression of DCIS to IDC in the context of three evolutionary models: independent lineages, evolutionary bottlenecks, and multiclonal invasion. We examine the evidence in support of these models and their relevance to the diagnosis and treatment of patients with DCIS. We also discuss how emerging technologies, such as single-cell sequencing, STAR-FISH, and imaging mass spectrometry, are likely to provide new insights into the evolution of this enigmatic disease. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558847/pdf
Ending Page	218
Page Count	11
Starting Page	208
e-ISSN	10969896
DOI	10.1002/path.4840
Journal	The Journal of Pathology
Issue Number	2
Volume Number	241
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-11-27
Access Restriction	Open
Subject Keyword	Journal: The Journal of Pathology Breast Cancer Breast Cancer Genomics Ductal Carcinoma in Situ Intratumour Heterogeneity Next-generation Sequencing Single-cell Sequencing
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing

Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinomain situ

Ductal carcinomain situ in breast carcinogenesis

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

Progression of ductal carcinoma in situ to invasive breast cancer: comparative genomic sequencing.

Ultra‐deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

Investigating Invasion in Ductal Carcinoma in Situ with Topographical Single Cell Genome Sequencing

Microsatellite instability in ductal carcinomain situ of the breast

Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer

Genome evolution in ductal carcinomain situ: invasion of the clones

Similar Documents

Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing

Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinomain situ

Ductal carcinomain situ in breast carcinogenesis

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

Progression of ductal carcinoma in situ to invasive breast cancer: comparative genomic sequencing.

Ultra‐deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

Investigating Invasion in Ductal Carcinoma in Situ with Topographical Single Cell Genome Sequencing

Microsatellite instability in ductal carcinomain situ of the breast

Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer

Genome evolution in ductal carcinomain situ: invasion of the clones