NDLI: Role of Glycine in the N-Methyl-d-Aspartate-Mediated Neuronal Cytotoxicity

Please wait, while we are loading the content...

Role of Glycine in the N-Methyl-d-Aspartate-Mediated Neuronal Cytotoxicity

Content Provider	Scilit
Author	Patel, Jitendra Zinkand, William C. Thompson, Carolann Keith, Richard Salama, Andre
Copyright Year	1990
Description	Journal: Journal of Neurochemistry Current evidence indicates that glutamate acting via the N-methyl-D-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine in NMDA neurotoxicity was examined. We demonstrate that NMDA-mediated neurotoxicity is markedly potentiated by glycine and other amino acids, e.g., D-serine. Putative glycine antagonists HA-966 and 7-chlorokynurenic acid were highly effective in preventing NMDA neurotoxicity, even in the absence of added glycine. The neuroprotective action of HA-966 and 7-chlorokynurenic acid, but not that of NMDA antagonists 3-(2-carboxypiperazine-4-yl)propylphosphonate and MK-801, could be reversed by glycine. These results indicate that glycine, operating through a strychinine-insensitive glycine site, plays a central permissive role in NMDA-mediated neurotoxicity.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1990.tb02329.x/pdf
Ending Page	854
Page Count	6
Starting Page	849
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1990.tb02329.x
Journal	Journal of Neurochemistry
Issue Number	3
Volume Number	54
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1990-03-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Excitatory Amino Acids N‐methyl‐d‐aspartate–glycine
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

N-Methyl-D-Aspartate Releases Excitatory Amino Acids in Rat Corpus Striatum In Vivo

Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons

Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur-Containing Amino Acids

Ethanol Inhibition of N-Methyl-D-Aspartate-Stimulated Endogenous Dopamine Release from Rat Striatal Slices: Reversal by Glycine

Identification and Characterization of an N-Methyl-D-Aspartate-Specific $L-[^{3}$H]Glutamate Recognition Site in Synaptic Plasma Membranes

Ethanol and Excitotoxicity in Cultured Cortical Neurons: Differential Sensitivity of N-Methyl-D-Aspartate and Sodium Nitroprusside Toxicity

Biochemical Responses Mediated by N-Methyl-d-Aspartate Receptors in Rat Cortical Slices Are Differentially Sensitive to Magnesium

$[^{3}$H]MK-801 Binding to N-Methyl-d-Aspartate Receptors Solubilized from Rat Brain: Effects of Glycine Site Ligands, Polyamines, Ifenprodil, and Desipramine

Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals

Role of Glycine in the N-Methyl-d-Aspartate-Mediated Neuronal Cytotoxicity

Similar Documents

N-Methyl-D-Aspartate Releases Excitatory Amino Acids in Rat Corpus Striatum In Vivo

Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons

Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur-Containing Amino Acids

Ethanol Inhibition of N-Methyl-D-Aspartate-Stimulated Endogenous Dopamine Release from Rat Striatal Slices: Reversal by Glycine

Identification and Characterization of an N-Methyl-D-Aspartate-Specific $L-[^{3}$H]Glutamate Recognition Site in Synaptic Plasma Membranes

Ethanol and Excitotoxicity in Cultured Cortical Neurons: Differential Sensitivity of N-Methyl-D-Aspartate and Sodium Nitroprusside Toxicity

Biochemical Responses Mediated by N-Methyl-d-Aspartate Receptors in Rat Cortical Slices Are Differentially Sensitive to Magnesium

$[^{3}$H]MK-801 Binding to N-Methyl-d-Aspartate Receptors Solubilized from Rat Brain: Effects of Glycine Site Ligands, Polyamines, Ifenprodil, and Desipramine

Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals

Role of Glycine in the N-Methyl-d-Aspartate-Mediated Neuronal Cytotoxicity