NDLI: A chemical shift encoding (CSE) approach for spectral selection in fluorine‐19 MRI

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A chemical shift encoding (CSE) approach for spectral selection in fluorine‐19 MRI

Content Provider	Scilit
Author	Ludwig, Kai D. Hernando, Diego Roberts, Nathan T. van Heeswijk, Ruud B. Fain, Sean B.
Copyright Year	2017
Description	Journal: Magnetic Resonance in Medicine To develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species. A multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7 T. Cramér-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determined from Cramér-Rao lower bound analysis. Cramér-Rao lower bound analysis for PFCE and ISO separation shows signal-to-noise performance is maximized with a 0.33 ms echo separation. A linear behavior (R2 = 0.987) between PFCE signal and known relative PFCE volume is observed in CSE reconstructed images using a mixed PFCE/ISO phantom. Effective spatial and spectral separation of PFCE and ISO is shown in phantoms and in vivo. Feasibility of a gradient-echo CSE acquisition and image reconstruction approach with optimized noise performance is demonstrated through fluorine-19 MRI of PFCE with effective removal of ISO signal contributions. Magn Reson Med 79:2183-2189, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811371/pdf
Ending Page	2189
Page Count	7
Starting Page	2183
e-ISSN	15222594
DOI	10.1002/mrm.26874
Journal	Magnetic Resonance in Medicine
Issue Number	4
Volume Number	79
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-08-22
Access Restriction	Open
Subject Keyword	Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Chemical Shift Encoding Magnetic Resonance Imaging
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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