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Chemical shift encoding (CSE) for sensitive fluorine‐19 MRI of perfluorocarbons with complex spectra
| Content Provider | Scilit |
|---|---|
| Author | van Heeswijk, Ruud B. Colotti, Roberto Darçot, Emeline Delacoste, Jean Pellegrin, Maxime Piccini, Davide Hernando, Diego |
| Copyright Year | 2017 |
| Description | Journal: Magnetic Resonance in Medicine To implement a fluorine-19 (19 F) chemical shift encoding (CSE) approach for the sensitive imaging of molecules with multi-resonance spectra to remove their chemical shift displacement (CSD) artifacts, and to characterize its sensitivity versus established pulse sequences. The feasibility of CSE spoiled gradient echo (GRE) and balanced steady-state free precession (bSSFP) was first demonstrated in a phantom study. The dependence of the sensitivity of CSE-bSSFP on several pulse sequence parameters was then established, after which the occurrence of out-of-plane excitation was assessed for 2D and 3D techniques. Next, the sensitivity (in mm-3 s-0.5 ) of both CSE techniques was compared to bSSFP ultrashort echo time (bSSFP-UTE) imaging and multi-chemical-shift-selective turbo spin echo (MCSS-TSE) in a second phantom study. Finally, the sensitivity of the CSE-bSSFP, bSSFP-UTE, and MCSS-TSE pulse sequences was compared in a preliminary in vivo mouse study. Both CSE approaches were successfully implemented and resulted in negligible residual CSD artifacts, while large-volume 3D acquisitions should be considered to reduce problems related to out-of-plane excitation. CSE-bSSFP was shown to have a higher sensitivity than the bSSFP-UTE and MCSS-TSE pulse sequences (15.8 ± 1.3 vs. 11.7 ± 1.0 vs. 13.3 ± 0.9 mm-3 s-0.5 , respectively, P < 0.001), whereas CSE-GRE technique had a lower sensitivity (4.8 ± 1.1 mm-3 s-0.5 ). CSE 19 F MR imaging enables the unambiguous visualization of compounds with complex spectra, and provides high sensitivity both in vitro and in vivo. Magn Reson Med 79:2724-2730, 2018. © 2017 International Society for Magnetic Resonance in Medicine. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821578/pdf |
| Ending Page | 2730 |
| Page Count | 7 |
| Starting Page | 2724 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.26895 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 5 |
| Volume Number | 79 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Chemical Shift Displacement Chemical Shift Encoding |
| Content Type | Text |
| Resource Type | Article |
