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Bone marrow dysplasia in patients with newly diagnosed acute myelogenous leukemia does not correlate with history of myelodysplasia or with remission rate and survival
| Content Provider | Scilit |
|---|---|
| Author | Ballen, Karen K. Gilliland, D. Gary Kalish, Leslie A. Shulman, Lawrence N. |
| Copyright Year | 1994 |
| Description | Journal: Cancer Background. The records and initial bone marrow studies of 106 patients with newly diagnosed acute myelogenous leukemia (AML) were analyzed retrospectively to determine whether bone marrow dysplasia was predictive of a previous myelodysplastic disorder or correlated with remission rate and survival. Methods. Bone marrow aspirates and biopsy specimens were reviewed in a blinded fashion; dysplasia was assessed in as objective a manner as possible by numerically scoring nine specific findings: erythrocyte multinuclearity, nuclear fragmentation, megaloblastic characteristics, leukocyte granulation abnormalities and nuclear malformations, Pelger-Huet cells, and megakaryocytic dysplasia (mononuclear megakaryocytes, micromegakaryocytes, and megakaryocytes with multiple distinct nuclei). Results. Dysplasia of the megakaryocytic line was seen in 34% of patients; 70% of the patients had erythrocyte dysplasia; and 68% had leukocyte dysplasia. Pelger-Huet cells were seen in bone marrow of 35% of the patients. Overall dysplasia score and specific dysplastic findings such as Pelger-Huet cells did not correlate with a known history of myelodysplasia (P = 0.47), cytogenetic abnormalities (P = 0.35), prior chemotherapy treatment with or without alkylating agents (P = 1.00), previous malignant disorders such as polycythemia vera (P = 1.00), remission rate (P = 0.93), or survival (P = 0.42). Multivariate analysis confirmed known independent risk factors for remission in this patient population, including age (P = 0.04), history of prior chemotherapy (P = 0.04), abnormalities in chromosomes 5, 7, or 8 (P = 0.02), and type of antileukemia therapy (P < 0.001). Conclusions. Bone marrow dysplasia is common in patients with AML and does not correlate with a history of myelodysplasia or predict outcome when patients are treated with standard intensive AML therapy. |
| Ending Page | 321 |
| Starting Page | 314 |
| ISSN | 2573508X |
| e-ISSN | 10970142 |
| DOI | 10.1002/1097-0142%2819940115%2973%3A2%3C314%3A%3Aaid-cncr2820730214%3E3.0.co%3B2-c |
| Journal | Cancer |
| Issue Number | 2 |
| Volume Number | 73 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1994-01-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Medical Laboratory Technology Acute Myelogenous Leukemia Myelodysplasia, Bone Marrow |
| Content Type | Text |
| Resource Type | Article |
