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$Ca^{2+}$-Independent Release of Glutamate During In Vitro Anoxia in Isolated Nerve Terminals
| Content Provider | Scilit |
|---|---|
| Author | Rubio, Inmaculada Torres, Magdalena Miras-Portugal, María Teresa Sánchez-Prieto, Jose |
| Copyright Year | 1991 |
| Description | Journal: Journal of Neurochemistry The effects of in vitro anoxia on the release of glutamate in isolated nerve terminals were studied. The extra-synaptosomal concentration of glutamate ([Glu]ext) under aerobic conditions was 2.3 microM and increased to 4.9 microM after 10 min of anoxia. However, when synaptosomes were incubated in the presence of lactate plus pyruvate instead of glucose, to prevent anaerobic glycolysis, anoxia induced an eightfold increase in the [Glu]ext. The accumulation of glutamate in the external medium during anoxia was Ca2+ independent and insensitive to a significant reduction of the Ca(2+)-dependent release of the amino acid. These results indicate that a Ca(2+)-independent efflux of cytoplasmic glutamate occurs during in vitro anoxia in isolated nerve terminals. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1991.tb08274.x/pdf |
| Ending Page | 1164 |
| Page Count | 6 |
| Starting Page | 1159 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1991.tb08274.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 4 |
| Volume Number | 57 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1991-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Glutamate Release Ca2+‐independent Release‐vesicular Release Nerve Terminals |
| Content Type | Text |
| Resource Type | Article |
