NDLI: Occurrence of a Large $Ca^{2+}$-Independent Release of Glutamate During Anoxia in Isolated Nerve Terminals (Synaptosomes)

Content Provider	Scilit
Author	Sanchez-Prieto, Jose González, Pilar
Copyright Year	1988
Description	Journal: Journal of Neurochemistry Isolated rat cerebral cortical synaptosomes made anoxic by addition of cyanide developed an inhibition of the $Ca^{2+}$-dependent release of glutamate 2 min after the addition of the metabolic inhibitor when the intrasynaptosomal ATP/ADP ratio decreased below 1.7. In contrast, cyanide induced a continuous efflux of glutamate through a $Ca^{2+}$-independent pathway that accounted for the release of 25% of total intrasynaptosomal glutamate in 5 min. The results suggest that a $Ca^{2+}$-independent release of glutamate could be implicated in the neurotoxic action of this amino acid during anoxia.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.1988.tb10611.x
Ending Page	1324
Page Count	3
Starting Page	1322
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1988.tb10611.x
Journal	Journal of Neurochemistry
Issue Number	4
Volume Number	50
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1988-04-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry
Content Type	Text
Resource Type	Article

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Occurrence of a Large $Ca^{2+}$-Independent Release of Glutamate During Anoxia in Isolated Nerve Terminals (Synaptosomes)