Loading...
Please wait, while we are loading the content...
Similar Documents
Regulation of the Clara Cell Secretory Protein/Uteroglobin Promoter in Lung
| Content Provider | Scilit |
|---|---|
| Author | Magnus, N. O. R. D. Cassel, Tobias N. Braun, Harald Suske, Guntram |
| Copyright Year | 2006 |
| Description | Journal: Annals of the New York Academy of Sciences Clara cell secretory protein/uteroglobin (CCSP/UG) is specifically expressed in the conducting airway epithelium of the lung in a differentiation‐dependent manner. The proximal promoter region of the rodent CCSP/UG gene directs Clara cell specificity. Previously, it was shown that the forkhead transcription factors HNF‐3α and β and the homeodomain factor TTF‐1 are important transcription factors acting through this region, suggesting that they contribute to cell specificity of the CCSP/UG gene. Members of the C/EBP family of transcription factors can also interact with elements of the proximal rat and mouse CCSP/UG promoters. The onset of C/EBPα expression in Clara cells correlates with the strong increase of CCSP/UG expression. Thus, C/EBPalpha; may play a crucial role for differentiation‐dependent CCSP/UG expression. Transfection studies demonstrate that C/EBPα and TTF‐1 can synergistically activate the murine CCSP/UG promoter. Altogether, these results suggest that C/EBPalpha;, TTF‐1, and HNF‐3 determine the Clara cell‐specific, differentiation‐dependent expression of the CCSP/UG gene in murine lung. The relative importance of these three transcription factors, however, differs in rabbits and humans. |
| Related Links | https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2000.tb05527.x |
| Ending Page | 165 |
| Page Count | 12 |
| Starting Page | 154 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2000.tb05527.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 923 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-01-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Biochemistry and Molecular Biology Transcription Factors Protein/uteroglobin |
| Content Type | Text |
| Resource Type | Article |
