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G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
| Content Provider | Scilit |
|---|---|
| Author | Arang, Nadia Gutkind, J. Silvio |
| Copyright Year | 2020 |
| Description | Journal: FEBS Letters G protein coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein‐mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoral therapeutic targets. |
| Ending Page | 4232 |
| Starting Page | 4201 |
| ISSN | 2573508X |
| e-ISSN | 18733468 |
| DOI | 10.1002/1873-3468.14017 |
| Journal | FEBS Letters |
| Issue Number | 24 |
| Volume Number | 594 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2020-12-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: FEBS Letters G Protein Coupled Receptors Signal Transduction Precision Medicine Cancer Metabolism |
| Content Type | Text |
| Resource Type | Article |
