NDLI: The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	O'Hayre, Morgan Vázquez-Prado, José Kufareva, Irina Stawiski, Eric W. Handel, Tracy M. Seshagiri, Somasekar Gutkind, J. Silvio
Description	Country affiliation: United States Author Affiliation: O'Hayre M ( Oral and Pharyngeal Cancer Branch, Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.)
Abstract	Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding G s), and that oncogenic activating mutations in genes encoding G q family members (GNAQ or GNA11) are present in ~66% and ~6% of melanomas arising in the eye and skin, respectively. Furthermore, nearly 20% of human tumours harbour mutations in GPCRs. Many human cancer-associated viruses also express constitutively active viral GPCRs. These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment.
File Format	HTM / HTML
ISSN	1474175X
e-ISSN	14741768
DOI	10.1038/nrc3521
Journal	Nature Reviews Cancer
Issue Number	6
Volume Number	13
Language	English
Publisher	Nature Publishing Group
Publisher Date	2013-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Heterotrimeric Gtp-binding Proteins Genetics Neoplasms Metabolism Receptors, G-protein-coupled Animals Gene Expression Gene Frequency Mutation Signal Transduction Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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