NDLI: UltrashortT_{2}$^{*}$relaxometry for quantitation of highly concentrated superparamagnetic iron oxide (SPIO) nanoparticle labeled cells

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UltrashortT_{2}$^{*}$relaxometry for quantitation of highly concentrated superparamagnetic iron oxide (SPIO) nanoparticle labeled cells

Content Provider	Scilit
Author	Liu, Wei Dahnke, Hannes Rahmer, Juergen Frank, Joseph A.
Copyright Year	2009
Description	Journal: Magnetic Resonance in Medicine A new method was developed to measure ultrashort T relaxation in tissues containing a focal area of superparamagnetic iron oxide (SPIO) nanoparticle‐labeled cells in which the T decay is too short to be accurately measured using regular gradient echo T mapping. The proposed method utilizes the relatively long T $_{2}$ relaxation of SPIO‐labeled cells and acquires a series of spin echo images with the readout echo shifted to sample the T decay curve. MRI experiments in phantoms and rats with SPIO‐labeled tumors demonstrated that it can detect ultrashort T down to 1 ms or less. The measured T values were about 10% higher than those from the ultrashort TE (UTE) technique. The shorter the TE, the less the measurements deviated from the UTE T mapping. Combined with the regular T mapping, this technique is expected to provide quantitation of highly concentrated iron‐labeled cells from direct cell transplantation. Magn Reson Med, 2009.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384488/pdf
Ending Page	766
Page Count	6
Starting Page	761
e-ISSN	15222594
DOI	10.1002/mrm.21923
Journal	Magnetic Resonance in Medicine
Issue Number	4
Volume Number	61
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-02-03
Access Restriction	Open
Subject Keyword	Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Superparamagnetic Iron Oxide Nanoparticles Cell Labeling T Relaxometry
Content Type	Text
Resource Type	Article

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