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7-day rescue therapy with ranitidine bismuth citrate after Helicobacter pylori treatment failure
| Content Provider | Scilit |
|---|---|
| Author | Gisbert, Javier Pérez Fuentes, J. Carpio, Daniel Tito, L. Guardiola, Jordi Tomás, A. Olivares, D. Calvet, Xavier |
| Copyright Year | 2005 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Quadruple rescue therapy requires a complex scheme with four drugs. To evaluate the efficacy of ranitidine bismuth citrate-tetracycline-metronidazole rescue regimen, and to compare two different metronidazole dose schemes. Prospective multicentre study including proton-pump inhibitor + clarithromycin + amoxicillin failures. Rescue regimen included two 7-day treatment: (i) ranitidine bismuth citrate (400 mg b.d.)-tetracycline (500 mg q.d.s.)-metronidazole (500 mg t.d.s.; RTM1); or (ii) the same regimen but with metronidazole 250 mg q.d.s. (RTM2). Eradication was confirmed with (13)C-urea breath test. A total of 150 patients were included (58 RTM1, 92 RTM2). All patients but two (one in each group) returned after treatment. About 86% in group RTM1 and 95% in RTM2 correctly took all the medications (P = 0.076). Per-protocol eradication rates with RTM1 and RTM2 were 74 (95% CI: 60-84) and 69% (59-78). The intention-to-treat eradication rates were 64 (51-75) and 70% (59-78; P > 0.05). The type of regimen was not associated with eradication in the multivariate analysis. Adverse effects were more frequent with RTM1 (41%) than with RTM2 (30%; P > 0.05). Seven-day triple rescue therapy with ranitidine bismuth citrate-tetracycline-metronidazole is effective for Helicobacter pylori eradication, and represents an encouraging alternative to quadruple therapy, with the advantage of simplicity. The administration of metronidazole every 6 h (together with tetracycline), and at a low dose (250 mg), achieves similar efficacy and is probably associated with a better compliance and a lower incidence of adverse effects. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2005.02465.x/pdf |
| Ending Page | 1253 |
| Page Count | 5 |
| Starting Page | 1249 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2005.02465.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 10 |
| Volume Number | 21 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2005-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Helicobacter Pylori Ranitidine Bismuth Multivariate Analysis |
| Content Type | Text |
| Resource Type | Article |
