Loading...
Please wait, while we are loading the content...
Similar Documents
Seven-day is more effective than 4-day ranitidine bismuth citrate-based triple therapy in eradication of Helicobacter pylori in children: a prospective randomized study
| Content Provider | Scilit |
|---|---|
| Author | Tam, Y. H. Yeung, C. K. Lee, K. H. |
| Copyright Year | 2006 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Helicobacter pylori infection is common in paediatric population. To date, there is still no universally accepted recommendation on the treatment of this infection in children. Ranitidine bismuth citrate-based triple therapy has been shown to be effective in H. pylori eradication in adults but its use has rarely been validated in children. To investigate the efficacy of ranitidine bismuth citrate-based triple therapy in eradication of H. pylori in children and to determine the shortest duration of treatment required. We conducted a prospective randomized study comparing ranitidine bismuth citrate plus amoxicillin plus clarithromycin given for 4 days vs. 7 days in H. pylori-infected children diagnosed by (13)C-urea breath test. Eradication was evaluated by repeat (13)C-urea breath test at 6 weeks after treatment. A total of 206 children were recruited (median age 12 years, 97 boys and 109 girls). Ninety-eight (47.6%) and 108 (52.4%) children were randomized to receive 7-day and 4-day regimen respectively. The eradication rate of 4-day treatment arm was 77.8% (both intention-to-treat and per protocol) compared with 88.8% (intention-to-treat, P = 0.036) and 89.7% (per protocol, P = 0.022) of 7-day regimen. There was no statistical difference in terms of side effects between the two groups. Seven-day ranitidine bismuth citrate-based triple therapy is an effective and well-tolerated treatment for eradication of H. pylori in children. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.02969.x/pdf |
| Ending Page | 86 |
| Page Count | 6 |
| Starting Page | 81 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2006.02969.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Helicobacter Pylori Ranitidine Bismuth Breath Test Bismuth Citrate Based Triple Triple Therapy |
| Content Type | Text |
| Resource Type | Article |
