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Distribution of the Major Cytochrome P450 (CYP) 2C9 Genetic Variants in a Saudi Population
| Content Provider | Scilit |
|---|---|
| Author | Mirghani, Rajaa A. Chowdhary, Gulnaz Elghazali, Gehad |
| Copyright Year | 2011 |
| Description | Journal: Basic & Clinical Pharmacology & Toxicology Cytochrome P450 (CYP) 2C9 is responsible for the metabolism of a number of widely used drugs such as oral anticoagulants, oral antidiabetics and non-steroidal anti-inflammatory drugs. The CYP2C9 is a genetically polymorphic enzyme. The most common allele is CYP2C9*1, while CYP2C9*2 and CYP2C9*3 are the less-frequent variants. The activity of the enzyme encoded by either CYP2C9 *2 or *3 variant is lower compared with that of the CYP2C9*1. The metabolism of most of the CYP2C9 substrates decreases in varying degrees in subjects carrying the CYP2C9 *2 or *3 allele. The aim of this study was to investigate the frequencies of the major variants of the CYP2C9 in Saudi Arabians. |
| Ending Page | 114 |
| Starting Page | 111 |
| ISSN | 2573508X |
| e-ISSN | 17427843 |
| DOI | 10.1111/j.1742-7843.2011.00692.x |
| Journal | Basic & Clinical Pharmacology & Toxicology |
| Issue Number | 2 |
| Volume Number | 109 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-03-28 |
| Access Restriction | Open |
| Subject Keyword | Journal: Basic & Clinical Pharmacology & Toxicology |
| Content Type | Text |
| Resource Type | Article |
