Loading...
Please wait, while we are loading the content...
Similar Documents
Frequency of cytochrome P450 2C9 mutant alleles in a Korean population
| Content Provider | Scilit |
|---|---|
| Author | Yoon, Young-Ran Shon, Ji-Hong Kim, Moon-Kyung Lim, Young-Chai Lee, Hye-Rang Park, Ji-Young Cha, In-June Shin, Jae-Gook |
| Copyright Year | 2001 |
| Description | Journal: British journal of clinical pharmacology Aims To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations. Methods Genotyping of CYP2C9*2 and CYP2C9*3 allelic variants was carried out in 574 Korean subjects by PCR and restriction fragment length pattern analysis. Results Thirteen of 574 subjects (2.3%) were heterozygous for CYP2C9*3 $(Ile_{359}$Leu), but no subjects with a CYP2C9*2 allele or homozygous for CYP2C9*3 were identified. The allele frequency of CYP2C9*3 in Korean subjects (0.0113, 95% CI 0.0066–0.0193) was similar to that of other East Asian populations, but was considerably lower than that of Caucasian populations. Conclusions CYP2C9*3 seems to be an allelic variant related to the functional polymorphism of CYP2C9, but this variant is rarely seen among Koreans compared with Caucasians. Routine genotyping of the CYP2C9*2 allele is considered to be unnecessary in Korean and East Asians, because this allele appears to be extremely rare or absent in these populations. |
| Related Links | http://europepmc.org/articles/pmc2015024?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2015024/pdf http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2001.00340.x/pdf |
| Ending Page | 280 |
| Page Count | 4 |
| Starting Page | 277 |
| e-ISSN | 13652125 |
| DOI | 10.1046/j.1365-2125.2001.00340.x |
| Journal | British journal of clinical pharmacology |
| Issue Number | 3 |
| Volume Number | 51 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2001-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: British journal of clinical pharmacology Medical Laboratory Technology |
| Content Type | Text |
| Resource Type | Article |
