NDLI: X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability

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X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability

Content Provider	Scilit
Author	Lin, Boren Xu, Da Leaman, Douglas W.
Copyright Year	2016
Description	Journal: FEBS Letters X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a cytokine-regulated, tumor necrosis factor (TNF) receptor-associated factor (TRAF) domain-containing protein that has a poorly defined cellular function. Here, we show that ectopically expressed XAF1 inhibits TNF-ɑ-induced NF-κB activation, whereas shRNA silencing of endogenous XAF1 augments it. Our data suggest that XAF1 may inhibit TNF-ɑ-induced NF-κB activation by disrupting the assembly of the TRADD/TRAF2/RIP1 complex (complex I) downstream of TNF receptor activation. XAF1 interacts with TRAF2 and inhibits TRAF2-dependent NF-κB activation, in part, by blocking TRAF2 polyubiquitination. Our findings also indicate that although XAF1 does not directly inhibit RIP1-dependent NF-κB activation, it binds RIP1 and disrupts RIP1/TRADD association. Our data suggest that XAF1 acts as a feedback regulator of the TNF receptor signaling pathway to suppress NF-κB activation.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154952/pdf
Ending Page	4392
Page Count	12
Starting Page	4381
e-ISSN	18733468
DOI	10.1002/1873-3468.12467
Journal	FEBS Letters
Issue Number	23
Volume Number	590
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-11-03
Access Restriction	Open
Subject Keyword	Journal: FEBS Letters Biochemistry and Molecular Biology Receptor Interacting Protein Kinase 1 Xiap Associated Factor 1 Inflammatory Response Nuclear Factor-kappa B Tumor Necrosis Factor Tumor Necrosis Factor Receptor-associated Factor 2
Content Type	Text
Resource Type	Article

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