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Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy
| Content Provider | Scilit |
|---|---|
| Author | Yoo, Seung-Chul Kim, Woo Young Yoon, Jong-Hyuck Chang, Suk-Joon Chang, Ki-Hong Ryu, Hee-Sug |
| Copyright Year | 2010 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica Objective. To evaluate the long-term outcome and ovarian function in premenarchal and adolescent patients with malignant ovarian germ cell tumors after fertility-preserving surgery and adjuvant chemotherapy. Design. Retrospective review of medical records. Setting. Ajou University Hospital, a tertiary care hospital in South Korea. Population. Forty-five patients with malignant ovarian germ cell tumors. Methods. A retrospective analysis of patients with malignant ovarian germ cell tumors was conducted and a statistical analysis was performed. Main outcome measures. There were 9 premenarchal and 16 adolescent patients; the median ages at diagnosis were 7 and 18 years, respectively. All patients were treated with fertility-preserving surgery. Seventeen of the patients received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (68.0%). There were no disease recurrences or deaths. Of the nine premenarchal patients, eight (88.9%) subsequently had normal menarche. Among the 16 adolescent patients, 15 (93.8%) resumed normal menstruation and 1 had premature ovarian failure. Conclusion. Premenarchal and adolescent patients with malignant ovarian germ cell tumors have excellent survival with fertility-preserving surgery and adjuvant chemotherapy. The majority of these patients can have normal menarche and menstruation. |
| Ending Page | 130 |
| Starting Page | 126 |
| ISSN | 00221295 |
| e-ISSN | 16000412 |
| DOI | 10.3109/00016340903348383 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 1 |
| Volume Number | 89 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Obstetrics and Gynecology Reproductive Biology Adolescent Patients Preserving Surgery Fertility Preserving Malignant Ovarian Germ |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
