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Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor
| Content Provider | Scilit |
|---|---|
| Author | Solheim, Olesya Skalleberg, Jacob Warncke, Torhild Ørstavik, Kristin Tropé, Claes Fosså, Sophie D. |
| Copyright Year | 2018 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica The aim was to evaluate "overall neuropathy", defined as peripheral paresthesias and Raynaud's phenomenon, in long-term survivors of malignant ovarian germ cell tumors (MOGCTs) treated with cisplatin-based chemotherapy (CBCT) MATERIAL AND METHODS: Ninety-three MOGCT survivors recorded in Norway in 1980-2009 (median follow-up: 15 years) were included in this analysis. Forty-nine received CBCT (CBCT group) and 44 received other or no chemotherapy (non-CBCT group). Applying the scale for chemotherapy-induced neurotoxicity, the prevalence of overall neuropathy (i.e., score >1 on a 0 to 3 scale) was compared between the two groups. 40 women from the CBCT group also underwent neurophysiological and neurological examinations; results from the neurological examination were graded according to the National Cancer Institute-Common Terminology Criteria for Adverse Effects version 4 (NCI-CTCAE scale v4). These women were then categorized into subgroups of low (≤3 cycles of CBCT, n=23) and high CBCT (≥4 cycles of CBCT, n=17) RESULTS: Twenty-eight (57%) women from the CBCT group reported overall neuropathy, compared to 20 (45%) in the non-CBCT group (p=0.06). Of the 40 MOGCT survivors in the CBCT group who underwent neurophysiological and neurological examinations, 14 (35%) showed NCI-CTCAE grade ≥1 signs or symptoms of peripheral neuropathy. Pathological findings of NCI-CTCAE grade 2 or 3 signs or symptoms were found in four survivors (10%) from the high CBCT subgroup, all of whom also showed objective signs of neuropathy CONCLUSIONS: Though about half of our MOGCT survivors reported overall neuropathy after CBCT, more severe pathological neurological/neurophysiological findings that impacted daily living were recorded in only 10% of them. Our observations of a similar prevalence of self-reported overall neuropathy in the CBCT and non-CBCT group, combined with limited objective neurological findings, warrant further study to increase the understanding of the specific patho-physiological pathways of long-term, CBCT-induced neuropathy. |
| Ending Page | 249 |
| Starting Page | 240 |
| ISSN | 00221295 |
| e-ISSN | 16000412 |
| DOI | 10.1111/aogs.13477 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 2 |
| Volume Number | 98 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-11-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Reproductive Biology Raynaud's Phenomenon Malignant Ovarian Germ Cell Tumors Cisplatin-based Chemotherapy. Peripheral Paresthesias |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
