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Fate of Histone Messenger RNA in Mengovirus-Infected Ehrlich Ascites Tumor Cells
| Content Provider | Scilit |
|---|---|
| Author | Gallwitz, Dieter Traub, Ulrike Traub, Peter |
| Copyright Year | 1977 |
| Description | Journal: Journal of Biological Inorganic Chemistry Histone mRNA was isolated from mengovirus-infected Ehrlich ascites tumor cells at various times postinfection and quantitated in a reticulocyte cell-free protein-synthesizing system. The amount of translatable histone mRNA decreases during the first hour postinfection by 30%, rises during the following 1-1.5 h by 10-15%, drops progressively in the further course of infection, and reaches 20% of the control at the end of the infectious cycle (8-9 h postinfection). On the basis of the relative histone mRNA contents, the histone-synthesizing potentials of mengovirus-infected Ehrlich ascites tumor cells are substantially higher throughout infection than actually expressed in vivo. This result indicates that the virus-induced shutoff of histone synthesis is not directly the consequence of inactivation or degradation of histone mRNA. Most of the histone mRNA recovered from mengovirus-infected Ehrlich ascites tumor cells is bound to ribosomes. Late in infection, certain mRNAs are co-isolated with histone mRNAs, very likely due to loss or shortening of poly(A) occurring after release of the mRNAs from polyribosomes. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1977.tb11963.x/pdf |
| Ending Page | 393 |
| Page Count | 7 |
| Starting Page | 387 |
| ISSN | 09498257 |
| e-ISSN | 14321327 |
| DOI | 10.1111/j.1432-1033.1977.tb11963.x |
| Journal | Journal of Biological Inorganic Chemistry |
| Issue Number | 2 |
| Volume Number | 81 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1977-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biological Inorganic Chemistry Tumor Cells Ascites Tumor Histone Messenger Mengovirus Infected Infected Ehrlich |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Inorganic Chemistry |
