Loading...
Please wait, while we are loading the content...
Similar Documents
Digestion of Ceramide 2-Aminoethylphosphonate, a Sphingolipid from the Jumbo Flying Squid Dosidicus gigas, in Mice
| Content Provider | Scilit |
|---|---|
| Author | Tomonaga, Nami Manabe, Yuki Sugawara, Tatsuya |
| Copyright Year | 2017 |
| Description | Journal: Lipids Ceramide 2-aminoethylphosphonate (CAEP), a sphingophosphonolipid containing a carbon–phosphorus bond, is frequently found in marine organisms and has a unique triene type of sphingoid base in its structure. CAEP has not been evaluated as a food ingredient, although it is generally contained in Mollusca organisms such as squids and shellfish, which are consumed worldwide. In this study, we aimed to elucidate the effects of CAEP as a food component by evaluating the digestion of CAEP extracted from the skin of the jumbo flying squid Dosidicus gigas. Our results revealed that dietary CAEP was digested to free sphingoid bases via ceramides by the mouse small intestinal mucosa. At pH 7.2, CAEP was hydrolyzed more rapidly than the major mammalian sphingolipid sphingomyelin; however, the hydrolysis of CAEP was similar to that of sphingomyelin at pH 9.0. Thus, the digestion of CAEP may be catalyzed by alkaline spingomyelinase and other enzymes. Our findings provide important insights into the digestion of the dietary sphingophosphonolipid CAEP in marine foods. |
| Ending Page | 362 |
| Starting Page | 353 |
| ISSN | 00221295 |
| e-ISSN | 15589307 |
| DOI | 10.1007/s11745-017-4239-0 |
| Journal | Lipids |
| Issue Number | 4 |
| Volume Number | 52 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-02-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Lipids Nutrition and Dietetics Dietary Sphingolipids Sphingoid Base |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology |
