NDLI: Ceramide aminoethylphosphonate from jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR

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Ceramide aminoethylphosphonate from jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR

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Fisheries Science : Volume 79, Issue 1, January 2013

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Ceramide aminoethylphosphonate from jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR

Content Provider	Springer Nature Link
Author	Komatsu, Masaharu Ichiyama, Naoki Kurimoto, Takashi Takumi, Shota Shiozaki, Kazuhiro Sugiyama, Yasumasa Furukawa, Tatsuhiko Ando, Seiichi Itonori, Saki Saito, Hiroaki
Copyright Year	2013
Abstract	We have previously established the method for isolation of ceramide aminoethylphosphonate (CAEP) from jumbo flying squid Dosidicus gigas. In this study, we performed a MTT assay to evaluate the safety of CAEP to the cell lines for the application to health food and supplements. The CAEP did not show any cytotoxicity to various HEK293-transfectant cells. Next, we elucidated the positive function of CAEP to the somatic cells. Recently, we have reported that hepatotoxin microcystin-LR was taken up into the hepatocytes mediated by hepatocellular uptake transporters OATP1B1 and OATP1B3, and the cells were induced cytotoxicity subsequently. Cytotoxicity of microcystin-LR to permanently OATP1B3-expressing HEK293-OATP1B3 cells rather than to HEK293-OATP1B1 cells was preferentially attenuated by CAEP in a concentration-dependent manner. In addition, the enzyme activity of serine/threonine phosphatase, which was inhibited by microcystin-LR, was recuperated by co-exposure to CAEP. Furthermore, microcystin-LR-induced cellular protein phosphorylation were disrupted by CAEP exposure. These results suggested that CAEP is a promising remedy and/or preventive medicine for liver damage with microcystin-LR.
Starting Page	313
Ending Page	320
Page Count	8
File Format	PDF
ISSN	09199268
Journal	Fisheries Science
Volume Number	79
Issue Number	2
e-ISSN	14442906
Language	English
Publisher	Springer Japan
Publisher Date	2013-01-11
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chemical prevention Ceramide aminoethylphosphonate Cytotoxicity Microcystin-LR OATP1B3 Fish & Wildlife Biology & Management Freshwater & Marine Ecology Food Science
Content Type	Text
Resource Type	Article
Subject	Aquatic Science

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