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Detecting pulmonary capillary blood pulsations using hyperpolarized xenon-129 chemical shift saturation recovery (CSSR) MR spectroscopy
| Content Provider | Scilit |
|---|---|
| Author | Ruppert, Kai Altes, Talissa A. Mata, Jaime F. Ruset, Iulian C. Hersman, F. William Mugler, John P. |
| Copyright Year | 2015 |
| Description | Journal: Magnetic Resonance in Medicine To investigate whether chemical shift saturation recovery (CSSR) MR spectroscopy with hyperpolarized xenon-129 is sensitive to the pulsatile nature of pulmonary blood flow during the cardiac cycle. A CSSR pulse sequence typically uses radiofrequency (RF) pulses to saturate the magnetization of xenon-129 dissolved in lung tissue followed, after a variable delay time, by an RF excitation and subsequent acquisition of a free-induction decay. Thereby it is possible to monitor the uptake of xenon-129 by lung tissue and extract physiological parameters of pulmonary gas exchange. In the current studies, the delay time was instead held at a constant value, which permitted observation of xenon-129 gas uptake as a function of breath-hold time. CSSR studies were performed in 13 subjects (10 healthy, 2 chronic obstructive pulmonary disease [COPD], 1 second-hand smoke exposure), holding their breath at total lung capacity. The areas of the tissue/plasma and the red-blood-cell peaks in healthy subjects varied by an average of 1.7±0.7% and 15.1±3.8%, respectively, during the cardiac cycle. In 2 subjects with COPD these peak pulsations were not detectable during at least part of the measurement period. CSSR spectroscopy is sufficiently sensitive to detect oscillations in the xenon-129 gas-uptake rate associated with the cardiac cycle. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154503/pdf |
| Ending Page | 1780 |
| Page Count | 10 |
| Starting Page | 1771 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.25794 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 4 |
| Volume Number | 75 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-05-28 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Cssr Spectroscopy Chemical Shift Saturation Recovery Hyperpolarized Xenon-129 |
| Content Type | Text |
| Resource Type | Article |
