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Central and Peripheral Cardiovascular Effects of Angiotensin III in Trout
| Content Provider | Scilit |
|---|---|
| Author | Mimassi, N. Lancien, F. Mével, J. C. Le |
| Copyright Year | 2009 |
| Description | Journal: Annals of the New York Academy of Sciences The present study was undertaken to determine the central and peripheral actions of trout angiotensin III (ANG III) on heart rate (HR) and mean dorsal aortic blood pressure (P(DA)) in the unanaesthetized rainbow trout. Intracerebroventricular injection of ANG III (5-100 pmol) produced a significant and dose-dependent increase in HR without significant change in P(DA). In contrast, when injected peripherally ANG III (5-50 pmol) evoked a significant and dose-dependent increase in P(DA). The hypertensive responses were accompanied by a bradycardia that reached significance only for the highest dose of ANG III tested. In conclusion, our results have shown that ANG III has potent and contrasting cardiovascular actions depending on whether its site of action is the brain or the peripheral circulation. Endogenous ANG III may have important physiological functions in teleost fishes. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2008.03643.x/pdf |
| Ending Page | 471 |
| Page Count | 3 |
| Starting Page | 469 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2008.03643.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 1163 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-04-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Peripheral Vascular Disease Intracerebroventricular Injection Intra‐arterial Injection |
| Content Type | Text |
| Resource Type | Article |
