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Abeta Vasoactivity in Vivo
| Content Provider | Scilit |
|---|---|
| Author | Suo, Zhiming Su, George Placzek, Andon Kundtz, Amy Humphrey, James Crawford, Fiona Mullan, Mike |
| Copyright Year | 2000 |
| Description | Journal: Annals of the New York Academy of Sciences Bilateral temporoparietal hypoperfusion has been frequently observed early in the Alzheimer's disease (AD) process. The beta-amyloid (A beta) peptide is believed to play a central role in the pathogenesis of AD. In vitro experiments have shown that freshly solubilized A beta enhances constriction of cerebral and peripheral vessels. We proposed that in vivo, A beta would also have vasoactive properties. To test this hypothesis, we intraarterially infused freshly solubilized A beta 1-40 in rats and observed changes in peripheral blood pressure, cerebral blood flow, and cerebrovascular resistance. We found that infusion of A beta in vivo significantly increased the blood pressure in hypotensive rats but not in normotensive and hypertensive rats. Moreover, A beta infusion also resulted in a decreased blood flow and increased vascular resistance specifically in cerebral cortex but not in heart or kidneys. These data suggest that A beta has a direct and specific constrictive effect on cerebral vessels in vivo, which may contribute to the cerebral hypoperfusion observed early in the AD process. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2000.tb06363.x/pdf |
| Ending Page | 163 |
| Page Count | 8 |
| Starting Page | 156 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2000.tb06363.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 903 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2000-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Peripheral Vascular Disease |
| Content Type | Text |
| Resource Type | Article |
