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In vivo generalized diffusion tensor imaging (GDTI) using higher-order tensors (HOT)
| Content Provider | Scilit |
|---|---|
| Author | Liu, Chunlei Mang, Sarah C. Moseley, Michael E. |
| Copyright Year | 2009 |
| Description | Journal: Magnetic Resonance in Medicine Generalized diffusion tensor imaging (GDTI) using higher-order tensor (HOT) statistics generalizes the technique of diffusion tensor imaging by including the effect of nongaussian diffusion on the signal of MRI. In GDTI-HOT, the effect of nongaussian diffusion is characterized by higher-order tensor statistics (i.e., the cumulant tensors or the moment tensors), such as the covariance matrix (the second-order cumulant tensor), the skewness tensor (the third-order cumulant tensor), and the kurtosis tensor (the fourth-order cumulant tensor). Previously, Monte Carlo simulations have been applied to verify the validity of this technique in reconstructing complicated fiber structures. However, no in vivo implementation of GDTI-HOT has been reported. The primary goal of this study is to establish GDTI-HOT as a feasible in vivo technique for imaging nongaussian diffusion. We show that probability distribution function of the molecular diffusion process can be measured in vivo with GDTI-HOT and be visualized with three-dimensional glyphs. By comparing GDTI-HOT to fiber structures that are revealed by the highest resolution diffusion-weighted imaging (DWI) possible in vivo, we show that the GDTI-HOT can accurately predict multiple fiber orientations within one white matter voxel. Furthermore, through bootstrap analysis we demonstrate that in vivo measurement of HOT elements is reproducible, with a small statistical variation that is similar to that of diffusion tensor imaging. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824337/pdf |
| Ending Page | 252 |
| Page Count | 10 |
| Starting Page | 243 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.22192 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 1 |
| Volume Number | 63 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Magnetic Resonance Imaging Diffusion-weighted Imaging Diffusiontensor Imaging Generalized Diffusion-tensor Image Non-gaussian Diffusion |
| Content Type | Text |
| Resource Type | Article |
