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In vivo diffusion tensor MRI of the human heart: Reproducibility of breath-hold and navigator-based approaches
| Content Provider | Scilit |
|---|---|
| Author | Nielles-Vallespin, Sonia Mekkaoui, Choukri Gatehouse, Peter Reese, Timothy G. Keegan, Jennifer Ferreira, Pedro F. Collins, Steve Speier, Peter Feiweier, Thorsten de Silva, Ranil Jackowski, Marcel P. Pennell, Dudley J. Sosnovik, David E. Firmin, David |
| Copyright Year | 2012 |
| Description | Journal: Magnetic Resonance in Medicine The aim of this study was to implement a quantitative in vivo cardiac diffusion tensor imaging (DTI) technique that was robust, reproducible, and feasible to perform in patients with cardiovascular disease. A stimulated-echo single-shot echo-planar imaging (EPI) sequence with zonal excitation and parallel imaging was implemented, together with a novel modification of the prospective navigator (NAV) technique combined with a biofeedback mechanism. Ten volunteers were scanned on two different days, each time with both multiple breath-hold (MBH) and NAV multislice protocols. Fractional anisotropy (FA), mean diffusivity (MD), and helix angle (HA) fiber maps were created. Comparison of initial and repeat scans showed good reproducibility for both MBH and NAV techniques for FA (P > 0.22), MD (P > 0.15), and HA (P > 0.28). Comparison of MBH and NAV FA (FAMBHday1 = 0.60 ± 0.04, FANAVday1 = 0.60 ± 0.03, P = 0.57) and MD (MDMBHday1 = 0.8 ± 0.2 × 10(-3) mm(2) /s, MDNAVday1 = 0.9 ± 0.2 × 10(-3) mm(2) /s, P = 0.07) values showed no significant differences, while HA values (HAMBHday1Endo = 22 ± 10°, HAMBHday1Mid-Endo = 20 ± 6°, HAMBHday1Mid-Epi = -1 ± 6°, HAMBHday1Epi = -17 ± 6°, HANAVday1Endo = 7 ± 7°, HANAVday1Mid-Endo = 13 ± 8°, HANAVday1Mid-Epi = -2 ± 7°, HANAVday1Epi = -14 ± 6°) were significantly different. The scan duration was 20% longer with the NAV approach. Currently, the MBH approach is the more robust in normal volunteers. While the NAV technique still requires resolution of some bulk motion sensitivity issues, these preliminary experiments show its potential for in vivo clinical cardiac diffusion tensor imaging and for delivering high-resolution in vivo 3D DTI tractography of the heart. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864770/pdf |
| Ending Page | 465 |
| Page Count | 12 |
| Starting Page | 454 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.24488 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 2 |
| Volume Number | 70 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-09-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Cardiac Diffusion Tensor Imaging Cardiac Diffusion-weighted Imaging Cardiovascular Magnetic Resonance Imaging Prospective Navigators |
| Content Type | Text |
| Resource Type | Article |
