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Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized$ ^{13}$ C imaging
| Content Provider | Scilit |
|---|---|
| Author | Gordon, Jeremy W. Vigneron, Daniel B. Larson, Peder E. Z. |
| Copyright Year | 2016 |
| Description | Journal: Magnetic Resonance in Medicine To develop symmetric echo planar imaging (EPI) and a reference scan framework for hyperpolarized 13 C metabolic imaging. Symmetric, ramp-sampled EPI with partial Fourier reconstruction was implemented on a 3T scanner. The framework for acquiring a reference scan on the 1 H channel and applied to 13 C data was described and validated in both phantoms and in vivo metabolism of [1-13 C]pyruvate. Ramp-sampled, symmetric EPI provided a substantial increase in the signal-to-noise ratio of the phantom experiments. The reference scan acquired on the 1 H channel yielded 13 C phantom images that varied in mean signal intensity <2%, compared with 13 C images reconstructed with a reference scan directly measured on the 13 C channel. The structural similarity index and dynamic time course from in vivo 13 C data further support the application of a 1 H reference scan to 13 C data to mitigate Nyquist ghost artifacts. Ramp-sampled, symmetric EPI with spectral-spatial excitation of a single metabolite provides a fast, robust, and clinically efficacious approach to acquire hyperpolarized 13 C dynamic molecular imaging data. The gains of this efficient sampling, combined with partial Fourier methods, enables large matrix sizes required for human studies. Magn Reson Med 77:826-832, 2017. © 2016 International Society for Magnetic Resonance in Medicine. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992668/pdf |
| Ending Page | 832 |
| Page Count | 7 |
| Starting Page | 826 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.26123 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 2 |
| Volume Number | 77 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2016-02-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Echoplanar Imaging Hyperpolarized 13c Reference Scan Spectroscopic Imaging |
| Content Type | Text |
| Resource Type | Article |
