NDLI: Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D$ ^{13}$ C magnetic resonance spectroscopic imaging

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Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D$ ^{13}$ C magnetic resonance spectroscopic imaging

Content Provider	Scilit
Author	Park, Ilwoo Hu, Simon Bok, Robert Ozawa, Tomoko Ito, Motokazu Mukherjee, Joydeep Phillips, Joanna J. James, C. David Pieper, Russell O. Ronen, Sabrina M. Vigneron, Daniel B. Nelson, Sarah J.
Copyright Year	2012
Description	Journal: Magnetic Resonance in Medicine High resolution compressed sensing hyperpolarized (13)C magnetic resonance spectroscopic imaging was applied in orthotopic human glioblastoma xenografts for quantitative assessment of spatial variations in (13)C metabolic profiles and comparison with histopathology. A new compressed sensing sampling design with a factor of 3.72 acceleration was implemented to enable a factor of 4 increase in spatial resolution. Compressed sensing 3D (13)C magnetic resonance spectroscopic imaging data were acquired from a phantom and 10 tumor-bearing rats following injection of hyperpolarized [1-(13)C]-pyruvate using a 3T scanner. The (13)C metabolic profiles were compared with hematoxylin and eosin staining and carbonic anhydrase 9 staining. The high-resolution compressed sensing (13)C magnetic resonance spectroscopic imaging data enabled the differentiation of distinct (13)C metabolite patterns within abnormal tissues with high specificity in similar scan times compared to the fully sampled method. The results from pathology confirmed the different characteristics of (13)C metabolic profiles between viable, non-necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630274/pdf
Ending Page	39
Page Count	7
Starting Page	33
e-ISSN	15222594
DOI	10.1002/mrm.24434
Journal	Magnetic Resonance in Medicine
Issue Number	1
Volume Number	70
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-07-31
Access Restriction	Open
Subject Keyword	Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Hyperpolarized 13c Mrsi Compressed Sensing Dynamic Nuclear Polarization
Content Type	Text
Resource Type	Article

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