NDLI: Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-β peptide(1-40) in mouse: involvement of an LRP-1-independent pathway

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Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-β peptide(1-40) in mouse: involvement of an LRP-1-independent pathway

Content Provider	Scilit
Author	Ito, Shingo Ueno, Takashi Ohtsuki, Sumio Terasaki, Tetsuya
Copyright Year	2010
Description	Journal: Journal of Neurochemistry The contribution of low-density lipoprotein receptor-related protein-1 (LRP-1) to the brain-to-blood amyloid-beta peptide (A beta) efflux transport across the blood-brain barrier (BBB) remains controversial. The purpose of the present study was to clarify whether or not LRP-1 plays a role in efflux transport of A beta at the BBB. After microinjection of [(125)I]activated alpha2-macroglobulin (alpha 2M), a typical LRP-1 ligand, into mouse secondary somatosensory cortex region under ketamine-xylazine anesthesia, residual radioactivity was not significantly decreased up to 90 min, whereas after microinjection of [(125)I]human A beta(1-40) [hA beta(1-40)], the residual radioactivity decreased time-dependently. Co-administration of receptor-associated protein, an inhibitor of LRP-1, did not influence [(125)I]hA beta(1-40) elimination from mouse brain, suggesting that members of the LDL receptor gene family, including LRP-1, do not contribute to hA beta(1-40) elimination from mouse brain across the BBB. There was no significant difference between the uptakes of [(125)I]activated alpha 2M and [(14)C]inulin by mouse brain slices, suggesting that activated alpha 2M was not significantly bound to and/or taken up by parenchymal cells. In conclusion, our results show that LRP-1 does not play a significant role in the brain-to-blood efflux transport of A beta(1-40) at the mouse BBB, but an unidentified transporter(s) appears to be involved.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06708.x/pdf
Ending Page	1363
Page Count	8
Starting Page	1356
e-ISSN	14714159
DOI	10.1111/j.1471-4159.2010.06708.x
Journal	Journal of Neurochemistry
Issue Number	5
Volume Number	113
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-04-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Alzheimer's Disease Amyloid‐β Peptide Blood‐brain Barrier
Content Type	Text
Resource Type	Article

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