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A new experimental model to study preneoplastic lesions in achalasia of the esophagus
| Content Provider | Scilit |
|---|---|
| Author | Vespúcio, Marcelo Vinícius Oliveira Paschoal, Ricardo Mesquita Zucoloto, Sérgio Garcia, Fábio Rogério Brosci Dalio, Marcelo Belini Soares, Edson Garcia Garcia, Sérgio Britto |
| Copyright Year | 2005 |
| Description | PURPOSE: Develop an experimental model to study esophageal preneoplastic lesions induced by diethylnitrosamine in rats with achalasia. METHODS: Male Wistar rats were divided into four groups: control - C (n=8); rats with megaesophagus - B (n=8); rats treated with DEN - D (n=15) and rats with megaesophagus plus DEN - BD (n=15). Megaesophagus can be experimentally obtained in rats by topical application of benzalkonium choride. The morphology and PCNA labeling index of the epithelium were evaluated. RESULTS: The morphometric analysis showed an increase in epithelial thickness in the animals of group BD (2166±1012mm²) when compared to the other groups (C = 878±278mm²; B = 1746±144mm² and D = 1691±697mm²), mainly due to basal layer hyperplasia, besides an increase in the keratin of the superficial layer. The PCNA labeling index in the basal layer was significantly higher in the group BD (0,695±0,111) when compared to the other groups (C = 0,490±0,132; B = 0,512±0,215 and D = 0,477±0,198). CONCLUSIONS: Our data confirm in an experimental model the previous observation in humans of increased epithelial cell proliferation during the esophageal carcinogenic process in achalasia and may be useful to further studies on the mechanisms of the esophageal carcinogenesis and the the design of follow-up endoscopic studies for patients with achalasia. |
| Related Links | http://www.scielo.br/pdf/acb/v20n6/26551.pdf |
| Ending Page | 421 |
| Page Count | 4 |
| Starting Page | 418 |
| ISSN | 01028650 |
| e-ISSN | 16782674 |
| DOI | 10.1590/s0102-86502005000600004 |
| Journal | Acta Cirurgica Brasileira |
| Issue Number | 6 |
| Volume Number | 20 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2005-12-01 |
| Access Restriction | Open |
| Subject Keyword | Acta Cirurgica Brasileira Gastroenterology and Hepatology Pediatrics and Child Health Esophageal Achalasia Animal Experimentation Acalasia Esofágica Experimentação Animal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
