NDLI: Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline.

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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline.

Content Provider	Scilit
Author	Isbil-Buyukcoskun, N. Gulec, G. Ozluk, K. Ulus, I. H.
Copyright Year	2001
Description	In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 microg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 microg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 microg, icv), was administered 3 min before choline. Twenty-five microg captopril did not block the pressor effect of choline, while 50 microg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.
Related Links	http://www.scielo.br/pdf/bjmbr/v34n6/3938m.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-879X2001000600018&lng=en&nrm=iso&tlng=en
Ending Page	820
Page Count	6
Starting Page	815
ISSN	0100879X
e-ISSN	1414431X
DOI	10.1590/s0100-879x2001000600018
Journal	Brazilian Journal of Medical and Biological Research
Issue Number	6
Volume Number	34
Language	English
Publisher	FapUNIFESP (SciELO)
Publisher Date	2001-06-01
Access Restriction	Open
Subject Keyword	Brazilian Journal of Medical and Biological Research Blood Pressure Renin Angiotensin System
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cell Biology Physiology Medicine Biochemistry Biophysics Immunology Pharmacology, Toxicology and Pharmaceutics

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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline.

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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline.