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Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer
| Content Provider | Scilit |
|---|---|
| Author | Ren, Shancheng Shao, Yaping Zhao, Xinjie Hong, Christopher S. Wang, Fubo Lu, Xin Li, Jia Ye, Guozhu Yan, Min Zhuang, Zheng Ping Xu, Chuanliang Xu, Guowang Sun, Yinghao |
| Copyright Year | 2016 |
| Description | Journal: Molecular & Cellular Proteomics Prostate cancer is a highly prevalent tumor affecting millions of men worldwide, but poor understanding of its pathogenesis has limited effective clinical management of patients. In addition to transcriptional profiling or transcriptomics, metabolomics is being increasingly utilized to discover key molecular changes underlying tumorigenesis. In this study, we integrated transcriptomics and metabolomics to analyze 25 paired human prostate cancer tissues and adjacent noncancerous tissues, followed by further validation of our findings in an additional cohort of 51 prostate cancer patients and 16 benign prostatic hyperplasia patients. We found several altered pathways aberrantly expressed at both metabolic and transcriptional levels, including cysteine and methionine metabolism, nicotinamide adenine dinucleotide metabolism, and hexosamine biosynthesis. Additionally, the metabolite sphingosine demonstrated high specificity and sensitivity for distinguishing prostate cancer from benign prostatic hyperplasia, particularly for patients with low prostate specific antigen level (0–10 ng/ml). We also found impaired sphingosine-1-phosphate receptor 2 signaling, downstream of sphingosine, representing a loss of tumor suppressor gene and a potential key oncogenic pathway for therapeutic targeting. By integrating metabolomics and transcriptomics, we have provided both a broad picture of the molecular perturbations underlying prostate cancer and a preliminary study of a novel metabolic signature, which may help to discriminate prostate cancer from normal tissue and benign prostatic hyperplasia. |
| Related Links | https://www.mcponline.org/content/mcprot/15/1/154.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762514/pdf http://www.mcponline.org/article/S1535947620337142/pdf |
| Ending Page | 163 |
| Page Count | 10 |
| Starting Page | 154 |
| ISSN | 15359476 |
| DOI | 10.1074/mcp.m115.052381 |
| Journal | Molecular & Cellular Proteomics |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Molecular & Cellular Proteomics Biochemical Research Prostate Cancer Integration of Metabolomics Metabolomics and Transcriptomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Analytical Chemistry Molecular Biology Biochemistry |
