NDLI: Defining the factors that affect solute permeation of gap junction channels

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Defining the factors that affect solute permeation of gap junction channels

Content Provider	Scilit
Author	Valiunas, Virginijus Cohen, Ira S. Brink, Peter R.
Copyright Year	2018
Description	Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes This review focuses on the biophysical properties and structure of the pore and vestibule of homotypic gap junction channels as they relate to channel permeability and selectivity. Gap junction channels are unique in their sole role to connect the cytoplasm of two adjacent cells. In general, these channels are considered to be poorly selective, possess open probabilities approximating unity, and exhibit mean open times ranging from milliseconds to seconds. These properties suggest that such channels can function as delivery pathways from cell to cell for solutes that are significantly larger than monovalent ions. We have taken quantitative data from published works concerning unitary conductance, ion flux, and permeability for homotypic connexin 43 (Cx43), Cx40, Cx26, Cx50, and Cx37, and performed a comparative analysis of conductance and/or ion/solute flux versus diffusion coefficient. The analysis of monovalent cation flux portrays the pore as equivalent to an aqueous space where hydrogen bonding and weak interactions with binding sites dominate. For larger solutes, size, shape and charge are also significant components in determining the permeation rate. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705451/pdf
ISSN	00052736
DOI	10.1016/j.bbamem.2017.07.002
Journal	Biochimica et Biophysica Acta (BBA) - Biomembranes
Issue Number	1
Volume Number	1860
Language	English
Publisher	Elsevier BV
Publisher Date	2018-01-01
Access Restriction	Open
Subject Keyword	Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Biophysics

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