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PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation
| Content Provider | Scilit |
|---|---|
| Author | Navarro-Requena, Claudia Weaver, Jessica D. Clark, Amy Y. Clift, Douglas A. Pérez-Amodio, Soledad Castaño, Óscar Zhou, Dennis W. García, Andrés J. Engel, Elisabeth |
| Copyright Year | 2017 |
| Description | Journal: Acta biomaterialia The use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and glass-ceramics have also been suggested as therapeutic agents for stimulating angiogenesis in soft tissues, but these effects need further evaluation in vivo. In this study, calcium-releasing particles and hMSC were combined within a hydrogel to examine their vasculogenic potential in vitro and in vivo. The particles provided sustained calcium release and showed proangiogenic stimulation in a chorioallantoic membrane (CAM) assay. The number of hMSC encapsulated in a degradable RGD-functionalized PEG hydrogel containing particles remained constant over time and IGF-1 release was increased. When implanted in the epidydimal fat pad of immunocompromised mice, this composite material improved cell survival and stimulated vessel formation and maturation. Thus, the combination of hMSC and calcium-releasing glass-ceramics represents a new strategy to achieve vessel stabilization, a key factor in the revascularization of ischemic tissues. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534820/pdf |
| Ending Page | 65 |
| Page Count | 13 |
| Starting Page | 53 |
| ISSN | 17427061 |
| e-ISSN | 18787568 |
| DOI | 10.1016/j.actbio.2017.12.009 |
| Journal | Acta biomaterialia |
| Volume Number | 67 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-12-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta biomaterialia Glass-ceramic Particles |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology |
