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The effects of social contact on cocaine intake in female rats
| Content Provider | Scilit |
|---|---|
| Author | Robinson, Andrea M. Fronk, Gaylen E. Zhang, Huailin Tonidandel, Scott Smith, Mark A. |
| Copyright Year | 2017 |
| Description | Journal: Drug and Alcohol Dependence Studies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the effects of social contact on cocaine intake in female rats, (2) examine the behavioral mechanisms by which social contact influences cocaine intake, and (3) examine whether the estrous cycle moderates the effects of social contact on cocaine intake. Female rats were assigned to either isolated or pair-housed conditions in which a social partner either had access to cocaine (cocaine partner) or did not have access to cocaine (abstinent partner). Pair-housed rats were tested in custom-built operant conditioning chambers that allowed both rats to be tested simultaneously in the same chamber. Rats housed with a cocaine partner self-administered more cocaine than isolated rats and rats housed with an abstinent partner. A behavioral economic analysis indicated that these differences were driven by a greater intensity of cocaine demand (i.e., greater intake at lower unit prices) in rats housed with a cocaine partner. Multivariate modeling revealed that the estrous cycle did not moderate the effects of social contact on cocaine intake. These findings indicate that: (1) social contact influences cocaine self-administration in females in a manner similar to that reported in males, (2) these effects are due to differences in the effects of social contact on the intensity of cocaine demand, and (3) these effects are consistent across all phases of the estrous cycle. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534368/pdf |
| Ending Page | 53 |
| Page Count | 6 |
| Starting Page | 48 |
| ISSN | 03768716 |
| DOI | 10.1016/j.drugalcdep.2017.03.027 |
| Journal | Drug and Alcohol Dependence |
| Volume Number | 177 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug and Alcohol Dependence Behavioral Sciences Biological Psychology Behavioral Economics Demand Curve Social Environment Social Learning Substance Use |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
