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(-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats
| Content Provider | Scilit |
|---|---|
| Author | Manuszak, M. Harding, W. Gadhiya, S. Ranaldi, R. |
| Copyright Year | 2018 |
| Description | Journal: Drug and alcohol dependence Dopamine receptors are implicated in cocaine reward and seeking. We hypothesize that (-)-stepholidine, a dopamine D1/D2/D3 multi-receptor agent, would be effective in reducing cocaine reward and seeking in an animal model. We investigated the effects of (-)-stepholidine in cue-induced reinstatement of cocaine seeking and cocaine self-administration (reward). Cue-induced reinstatement experiment: Rats were trained to press a lever reinforced by cocaine (1 mg/kg/injection) for 15 consecutive daily sessions, after which the response was extinguished by withholding cocaine and cocaine-paired cues (light and pump activation). This was followed by a cue-induced reinstatement test where subjects were exposed to two cocaine cue presentations and presses on the active lever produced cues. Subjects were treated with one of four (-)-stepholidine doses prior to the reinstatement test. Cocaine self-administration (reward) experiment: Rats were trained to self-administer cocaine under a progressive ratio schedule of reinforcement. After stable breakpoints were established, rats were injected with four doses of (-)-stepholidine prior to testing; each dose was injected prior to a separate test session with no-treatment sessions intervening to re-establish break points. (-)-Stepholidine significantly reduced cue-induced reinstatement of cocaine seeking in a dose-related manner. Additionally, (-)-stepholidine significantly reduced break points for cocaine reward. (-)-Stepholidine did not significantly affect locomotor activity. (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine reward, suggesting that it may be useful in treating relapse in cocaine addiction. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062455/pdf |
| Ending Page | 54 |
| Page Count | 6 |
| Starting Page | 49 |
| ISSN | 03768716 |
| DOI | 10.1016/j.drugalcdep.2018.04.030 |
| Journal | Drug and alcohol dependence |
| Volume Number | 189 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug and alcohol dependence Behavioral Sciences Substance Use Disorder |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
