Loading...
Please wait, while we are loading the content...
Similar Documents
Dosimetric and radiobiological comparison of TG-43 and Monte Carlo calculations in 192Ir breast brachytherapy applications
| Content Provider | Scilit |
|---|---|
| Author | Peppa, V. Pappas, E. P. Karaiskos, P. Major, T. Polgár, C. Papagiannis, P. |
| Copyright Year | 2016 |
| Description | Journal: Physica Medica Purpose To investigate the clinical significance of introducing model based dose calculation algorithms (MBDCAs) as an alternative to TG-43 in$ ^{192}$Ir interstitial breast brachytherapy. Materials and methods A 57 patient cohort was used in a retrospective comparison between TG-43 based dosimetry data exported from a treatment planning system and Monte Carlo (MC) dosimetry performed using MCNP v. 6.1 with plan and anatomy information in DICOM-RT format. Comparison was performed for the target, ipsilateral lung, heart, skin, breast and ribs, using dose distributions, dose-volume histograms (DVH) and plan quality indices clinically used for plan evaluation, as well as radiobiological parameters. Results TG-43 overestimation of target DVH parameters is statistically significant but small (less than 2% for the target coverage indices and 4% for homogeneity indices, on average). Significant dose differences (>5%) were observed close to the skin and at relatively large distances from the implant leading to a TG-43 dose overestimation for the organs at risk. These differences correspond to low dose regions (<50% of the prescribed dose), being less than 2% of the prescribed dose. Detected dosimetric differences did not induce clinically significant differences in calculated tumor control probabilities (mean absolute difference <0.2%) and normal tissue complication probabilities. Conclusion While TG-43 shows a statistically significant overestimation of most indices used for plan evaluation, differences are small and therefore not clinically significant. Improved MBDCA dosimetry could be important for re-irradiation, technique inter-comparison and/or the assessment of secondary cancer induction risk, where accurate dosimetry in the whole patient anatomy is of the essence. |
| Related Links | http://www.physicamedica.com/article/S1120179716309437/pdf |
| Ending Page | 1251 |
| Page Count | 7 |
| Starting Page | 1245 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2016.09.020 |
| Journal | Physica Medica |
| Issue Number | 10 |
| Volume Number | 32 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-10-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Radiology, Nuclear Medicine and Imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
