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Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations
| Content Provider | Scilit |
|---|---|
| Author | Petringa, Giada Romano, F. Manti, L. Pandola, L. Attili, A. Cammarata, Francesco Paolo Cuttone, G. Forte, G. Manganaro, L. Pipek, J. Pisciotta, Pietro Russo, G. Cirrone, G. A. P. |
| Copyright Year | 2019 |
| Description | Journal: Physica Medica The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines. |
| Related Links | http://www.physicamedica.com/article/S1120179719300183/pdf |
| Ending Page | 80 |
| Page Count | 9 |
| Starting Page | 72 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2019.01.018 |
| Journal | Physica Medica |
| Volume Number | 58 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Nuclear Energy and Engineering Radiobiological Model Survival Fraction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
