NDLI: Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer

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Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer

Content Provider	Scilit
Author	Lin, Chang-Ching Lo, Miao-Chia Moody, Rebecca Jiang, Hui Harouaka, Ramdane Stevers, Nicholas Tinsley, Samantha Gasparyan, Mari Wicha, Max Sun, Duxin
Copyright Year	2018
Description	Journal: Cancer letters Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible for chemoresistance and metastasis. In this study, we identify LRP8 as a novel positive regulator of BCSCs in TNBC. LRP8 is highly expressed in TNBC compared to other breast cancer subtypes and its genomic locus is amplified in 24% of TNBC tumors. Knockdown of LRP8 in TNBC cell lines inhibits Wnt/β-catenin signaling, decreases BCSCs, and suppresses tumorigenic potential in xenograft models. LRP8 knockdown also induces a more differentiated, luminal-epithelial phenotype and thus sensitizes the TNBC cells to chemotherapy. Together, our study highlights LRP8 as a novel therapeutic target for TNBC as inhibition of LRP8 can attenuate Wnt/β-catenin signaling to suppress BCSCs.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945120/pdf
Ending Page	173
Page Count	9
Starting Page	165
ISSN	03043835
DOI	10.1016/j.canlet.2018.09.022
Journal	Cancer letters
Volume Number	438
Language	English
Publisher	Elsevier BV
Publisher Date	2018-09-15
Access Restriction	Open
Subject Keyword	Journal: Cancer letters Research and Experimental Medicine Triple-negative Breast Cancer Breast Cancer Stem Cells Wnt/β-catenin Signaling
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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