NDLI: Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies

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Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies

Content Provider	Scilit
Author	Vornhagen, Jay Waldorf, Kristina M. Adams Rajagopal, Lakshmi
Copyright Year	2017
Description	Journal: Trends in Microbiology Group B streptococcus (GBS) or Streptococcus agalactiae is a β-hemolytic, Gram-positive bacterium that is a leading cause of neonatal infections. GBS commonly colonizes the lower gastrointestinal and genital tracts and, during pregnancy, neonates are at risk of infection. Although intrapartum antibiotic prophylaxis during labor and delivery has decreased the incidence of early-onset neonatal infection, these measures do not prevent ascending infection that can occur earlier in pregnancy leading to preterm births, stillbirths, or late-onset neonatal infections. Prevention of GBS infection in pregnancy is complex and is likely influenced by multiple factors, including pathogenicity, host factors, vaginal microbiome, false-negative screening, and/or changes in antibiotic resistance. A deeper understanding of the mechanisms of GBS infections during pregnancy will facilitate the development of novel therapeutics and vaccines. Here, we summarize and discuss important advancements in our understanding of GBS vaginal colonization, ascending infection, and preterm birth.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650539/pdf http://www.cell.com/article/S0966842X17301270/pdf
Ending Page	931
Page Count	13
Starting Page	919
ISSN	0966842X
e-ISSN	18784380
DOI	10.1016/j.tim.2017.05.013
Journal	Trends in Microbiology
Issue Number	11
Volume Number	25
Language	English
Publisher	Elsevier BV
Publisher Date	2017-06-17
Access Restriction	Open
Subject Keyword	Journal: Trends in Microbiology Obstetrics and Gynecology Ascending Infection Group B Streptococcus Preterm Birth Vaginal Colonization Infection
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Microbiology Microbiology (medical)

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Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies