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Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy.
| Content Provider | Europe PMC |
|---|---|
| Author | Farr, Alex Sustr, Valentina Kiss, Herbert Rosicky, Ingo Graf, Alexandra Makristathis, Athanasios Foessleitner, Philipp Petricevic, Ljubomir |
| Abstract | This study aimed to evaluate the potential of oral probiotics to eradicate vaginal GBS colonization during the third trimester of pregnancy. We screened 1058 women for GBS colonization at 33-37 gestational weeks using a combination of vaginal-to-rectal swab and culture-based methods. Women who tested GBS positive were randomized to either the verum group, receiving a dietary probiotic supplement of four viable strains of Lactobacillus twice-daily for 14 days, or to the placebo group. Women underwent follow-up smears, whereat GBS colonization upon follow-up was considered the primary endpoint. We found that 215 women (20.3%) were positive for GBS upon screening, of which 82 (38.1%) were eligible for study inclusion; 41 (50%) of these were randomized to the verum and placebo groups each. After treatment, 21/33 (63.6%) members of the verum group, and 21/27 (77.8%) of the placebo group were still GBS positive (p = 0.24). Four (9.8%) women in the verum group and one (2.4%) in the placebo group experienced preterm birth (p = 0.20); smokers showed significantly higher rates of preterm birth (p = 0.03). Hence, the findings did not support the hypothesis that oral probiotics can eradicate GBS during pregnancy, although we observed a trend toward reduced GBS persistence after probiotic intake. |
| Journal | Scientific Reports [Sci Rep] |
| Volume Number | 10 |
| DOI | 10.1038/s41598-020-76896-4 |
| PubMed Central reference number | PMC7665007 |
| Issue Number | 1 |
| PubMed reference number | 33184437 |
| e-ISSN | 20452322 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2020-11-12 |
| Publisher Place | London |
| Access Restriction | Open |
| Subject Keyword | Microbiology Applied microbiology Clinical microbiology Risk factors Disease prevention Neonatology Preterm birth |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
