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Validation of Normalized Singular Spectrum Area as a Classifier for Molecularly Targeted Microbubble Adherence
| Content Provider | Scilit |
|---|---|
| Author | Herbst, Elizabeth B. Unnikrishnan, Sunil Klibanov, Alexander L. Mauldin, F. William Hossack, John A. |
| Copyright Year | 2019 |
| Description | Journal: Ultrasound in medicine & biology Ultrasound molecular imaging is a diagnostic technique wherein molecularly targeted microbubble contrast agents are imaged to reveal disease markers on the blood vessel endothelium. Currently, microbubble adhesion to affected tissue can be quantified using differential targeted enhancement (dTE), which measures the late enhancement of adherent microbubbles through administration of destructive ultrasound pressures. In this study, we investigated a statistical parameter called the normalized singular spectrum area (NSSA) as a means to detect microbubble adhesion without microbubble destruction. We compared the signal differentiation capability of NSSA with matched dTE measurements in a mouse hindlimb tumor model. Results indicated that NSSA-based signal classification performance matches dTE when differentiating adherent microbubble from non-adherent microbubble signals (receiver operating characteristic area under the curve = 0.95), and improves classification performance when differentiating microbubble from tissue signals (p < 0.005). NSSA-based signal classification eliminates the need for destruction of contrast, and may offer better sensitivity, specificity and the opportunity for real-time microbubble detection and classification. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480935/pdf http://www.umbjournal.org/article/S0301562919302364/pdf |
| Ending Page | 2501 |
| Page Count | 9 |
| Starting Page | 2493 |
| ISSN | 03015629 |
| e-ISSN | 1879291X |
| DOI | 10.1016/j.ultrasmedbio.2019.05.026 |
| Journal | Ultrasound in medicine & biology |
| Issue Number | 9 |
| Volume Number | 45 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-06-18 |
| Access Restriction | Open |
| Subject Keyword | Journal: Ultrasound in medicine & biology Ultrasound Molecular Imaging Differential Targeted Enhancement Normalized Singular Spectrum Area |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Acoustics and Ultrasonics Biophysics Radiological and Ultrasound Technology |
