NDLI: Ultrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion

Please wait, while we are loading the content...

Ultrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion

Content Provider	Scilit
Author	Yu, Gary Z. Istvanic, Filip Chen, Xucai Nouraie, Mehdi Shiva, Sruti Straub, Adam C. Pacella, John J.
Copyright Year	2019
Description	Journal: Ultrasound in Medicine & Biology Microvascular obstruction is a common repercussion of percutaneous coronary intervention for distal microembolization, ischemia–reperfusion injury and inflammation, which increases post-myocardial infarction heart failure and mortality. Ultrasound-targeted microbubble cavitation (UTMC) may resolve microvascular obstruction while activating endothelial nitric oxide synthase (eNOS) and increasing endothelium-derived nitric oxide (NO) bioavailability. Nitrite, a cardioprotective agent, offers an additional source of NO and potential synergy with UTMC. UTMC and nitrite co-therapy increased microvascular perfusion and NO concentration in a rat hindlimb model. Using N-nitro-L-arginine methyl ester for eNOS blockade, we found a three-way interaction effect between nitrite, UTMC and eNOS on microvascular perfusion and NO production. Modulating ultrasound peak negative acoustic pressure (0.33–1.5 MPa) significantly affected outcomes, while microbubble dosage (2 × $10^{8}$ bubbles/mL, 1.5 mL/h to 1 × $10^{9}$ bubbles/mL, 3 mL/h) did not. Nitrite co-therapy also protected against oxidative stress. Comparison of nitrite to sodium nitroprusside with UTMC revealed synergistic effects were specific to nitrite. Synergy between UTMC and nitrite holds therapeutic potential for cardiovascular disease.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010556/pdf http://www.umbjournal.org/article/S0301562919315480/pdf
Ending Page	678
Page Count	12
Starting Page	667
ISSN	03015629
e-ISSN	1879291X
DOI	10.1016/j.ultrasmedbio.2019.10.012
Journal	Ultrasound in Medicine & Biology
Issue Number	3
Volume Number	46
Language	English
Publisher	Elsevier BV
Publisher Date	2019-12-03
Access Restriction	Open
Subject Keyword	Journal: Ultrasound in Medicine & Biology Peripheral Vascular Disease
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Acoustics and Ultrasonics Biophysics Radiological and Ultrasound Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Diagnostic Ultrasound High Mechanical Index Impulses Restore Microvascular Flow in Peripheral Arterial Thromboembolism

Ultrasound Imaging of Microbubble Activity during Sonoporation Pulse Sequences

Nitric oxide pre-treatment enhances atheroma component highlighting in vivo with ICAM-1 targeted echogenic liposomes

Nitric Oxide-Enhanced Molecular Imaging of Atheroma using Vascular Cellular Adhesion Molecule-1 Targeted Echogenic Immunoliposomes

GENE THERAPY OF CARCINOMA USING ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION

CORRELATION OF CAVITATION WITH ULTRASOUND ENHANCEMENT OF THROMBOLYSIS

Non-Invasive Thrombolysis Using Pulsed Ultrasound Cavitation Therapy – Histotripsy

CAVITATION THRESHOLD OF MICROBUBBLES IN GEL TUNNELS BY FOCUSED ULTRASOUND

Mechanotransduction of Ultrasound is Frequency Dependent Below the Cavitation Threshold

Ultrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion

Similar Documents

Diagnostic Ultrasound High Mechanical Index Impulses Restore Microvascular Flow in Peripheral Arterial Thromboembolism

Ultrasound Imaging of Microbubble Activity during Sonoporation Pulse Sequences

Nitric oxide pre-treatment enhances atheroma component highlighting in vivo with ICAM-1 targeted echogenic liposomes

Nitric Oxide-Enhanced Molecular Imaging of Atheroma using Vascular Cellular Adhesion Molecule-1 Targeted Echogenic Immunoliposomes

GENE THERAPY OF CARCINOMA USING ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION

CORRELATION OF CAVITATION WITH ULTRASOUND ENHANCEMENT OF THROMBOLYSIS

Non-Invasive Thrombolysis Using Pulsed Ultrasound Cavitation Therapy – Histotripsy

CAVITATION THRESHOLD OF MICROBUBBLES IN GEL TUNNELS BY FOCUSED ULTRASOUND

Mechanotransduction of Ultrasound is Frequency Dependent Below the Cavitation Threshold

Ultrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion