NDLI: Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies

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Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies

Content Provider	Scilit
Author	Haase, Volker H.
Copyright Year	2017
Description	Journal: Experimental cell research The oxygen-sensitive hypoxia-inducible factor (HIF) pathway plays a central role in the control of erythropoiesis and iron metabolism. The discovery of prolyl hydroxylase domain (PHD) proteins as key regulators of HIF activity has led to the development of inhibitory compounds that are now in phase 3 clinical development for the treatment of renal anemia, a condition that is commonly found in patients with advanced chronic kidney disease. This review provides a concise overview of clinical effects associated with pharmacologic PHD inhibition and was written in memory of Professor Lorenz Poellinger.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507591/pdf
Ending Page	165
Page Count	6
Starting Page	160
ISSN	00144827
e-ISSN	10902422
DOI	10.1016/j.yexcr.2017.05.004
Journal	Experimental cell research
Issue Number	2
Volume Number	356
Language	English
Publisher	Elsevier BV
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Journal: Experimental cell research Urology and Nephrology Chronic Kidney Disease Clinical Trials Hypoxia-inducible Factor Prolyl Hydroxylase Domain
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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