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Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience
| Content Provider | Scilit |
|---|---|
| Author | Sanghani, Neil S. Haase, Volker H. |
| Copyright Year | 2019 |
| Description | Journal: Advances in Chronic Kidney Disease Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism. Small molecule inhibitors of prolyl hydroxylase domain dioxygenases (HIF-PHI [prolyl hydroxylase inhibitor]) stimulate the production of endogenous erythropoietin and improve iron metabolism resulting in efficacious anemia management in patients with CKD. Three oral HIF-PHIs—daprodustat, roxadustat, and vadadustat—have now advanced to global phase III clinical development culminating in the recent licensing of roxadustat for oral anemia therapy in China. Here, we survey current clinical experience with HIF-PHIs, discuss potential therapeutic advantages, and deliberate over safety concerns regarding long-term administration in patients with renal anemia. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318915/pdf http://www.ackdjournal.org/article/S1548559519300928/pdf |
| Ending Page | 266 |
| Page Count | 14 |
| Starting Page | 253 |
| ISSN | 15485595 |
| e-ISSN | 15485609 |
| DOI | 10.1053/j.ackd.2019.04.004 |
| Journal | Advances in Chronic Kidney Disease |
| Issue Number | 4 |
| Volume Number | 26 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Advances in Chronic Kidney Disease Urology and Nephrology Chronic Kidney Disease Prolyl Hydroxylase Domain Hypoxia-inducible Factor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
