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Interplatform reproducibility of liver and spleen stiffness measured with MR elastography
| Content Provider | Scilit |
|---|---|
| Author | Yasar, Temel Kaya Wagner, Mathilde Bane, Octavia Besa, Cecilia Babb, James S. Kannengiesser, Stephan Fung, Maggie Ehman, Richard L. Taouli, Bachir |
| Copyright Year | 2015 |
| Description | Journal: Journal of Magnetic Resonance Imaging (JMRI) To assess interplatform reproducibility of liver stiffness (LS) and spleen stiffness (SS) measured with magnetic resonance elastography (MRE) based on a 2D gradient echo (GRE) sequence. This prospective Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved study involved 12 subjects (five healthy volunteers and seven patients with liver disease). A multislice 2D-GRE-based MRE sequence was performed using two systems from different vendors (3.0T GE and 1.5T Siemens) on the same day. Two independent observers measured LS and SS on confidence maps. Bland-Altman analysis (with coefficient of reproducibility, CR), coefficient of variability (CV), and intraclass correlation (ICC) were used to analyze interplatform, intra- and interobserver variability. Human data were validated using a gelatin-based phantom. There was excellent reproducibility of phantom stiffness measurement (CV 4.4%). Mean LS values were 3.44-3.48 kPa and 3.62-3.63 kPa, and mean SS values were 7.54-7.91 kPa and 8.40-8.85 kPa at 3.0T and 1.5T for observers 1 and 2, respectively. The mean CVs between platforms were 9.2%-11.5% and 13.1%-14.4% for LS and SS, respectively, for observers 1 and 2. There was excellent interplatform reproducibility (ICC >0.88 and CR 0.99, CV 0.97, CV and CR <16%). This study demonstrates that 2D-GRE MRE provides platform- and observer-independent LS and SS measurements. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031410/pdf |
| Ending Page | 1072 |
| Page Count | 9 |
| Starting Page | 1064 |
| e-ISSN | 15222586 |
| DOI | 10.1002/jmri.25077 |
| Journal | Journal of Magnetic Resonance Imaging (JMRI) |
| Issue Number | 5 |
| Volume Number | 43 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-10-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging Interplatform Mre Liver Stiffness Magnetic Resonance Elastography Spleen Stiffness |
| Content Type | Text |
| Resource Type | Article |
