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Epstein-Barr virus susceptibility of normal human B lymphocyte populations.
| Content Provider | Scilit |
|---|---|
| Author | Aman, P. Ehlin-Henriksson, B. Klein, G. |
| Copyright Year | 1984 |
| Description | Human blood and tonsil B lymphocytes were fractionated on density gradients and tested for virus binding and penetration into the cells. Epstein-Barr Virus (EBV) transformation was detected by immunofluorescence staining for EBV-determined nuclear antigen (EBNA). EBV bound to and penetrated all B cell populations, but only the high density populations were transformed. Activated B lymphocytes were found in the low density fractions and these cells were resistant to EBV infection. Infected and noninfected B lymphocytes were density-analyzed during in vitro culture. A spontaneous, not virus-induced, density decrease was found to precede the production of EBNA. Cells remaining at high density never expressed EBNA. The results suggest that EBV can transform only small resting B lymphocytes and that a virus-independent activation of the infected cells induces the EBNA production and transformation. |
| Related Links | http://jem.rupress.org/content/159/1/208.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187189/pdf |
| Ending Page | 220 |
| Page Count | 13 |
| Starting Page | 208 |
| DOI | 10.1084/jem.159.1.208 |
| Journal | The Journal of experimental medicine |
| Issue Number | 1 |
| Volume Number | 159 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1984-01-01 |
| Access Restriction | Open |
| Subject Keyword | Virology Virus Lymphocytes Density Cells Antigen Ebna Ebv Epstein Penetrated Barr Journal: The Journal of experimental medicine (Vol- 159, Issue- 1) |
| Content Type | Text |
